Publications
MCT1-dependent mitochondrial lactate import sustains cardiac metabolism
Ahmad A Cluntun, Joseph R Visker, Jesse N Velasco-Silva, James Carrington, Luis Cedeño-Rosario, Giulia C Napoli, Ji Eon Kim, Thirupura S Shankar, Marisa J Brothwell, Rana Hamouche, Álvaro J Narbona-Pérez, Jing Ling, Ashish G Toshniwal, Hayden K Low, Corey N Cunningham, David R Eberhardt, Jing Li, Claire E Stanley, Queren A Alcantara, Tarun Yadav, Ryan L Maves, Wojciech I Swiatek, Nicholas A Offei, Bhavya Blaze, Sumangala P Shetty, Dipayan Chaudhuri, Tingting Hong, Jeffery D Rothstein, Deborah M Muoio, Joao A Paulo, Steven P Gygi, Eleni Tseliou, Sutip Navankasattusas, James E Cox, Katsuhiko Funai, Stavros G Drakos, Jared Rutter, Gregory S Ducker
Nature. 2026 Oct 28 PMID: 42951956
Joseph R Visker, Eleni Tseliou, Christos P Kyriakopoulos, Rana Hamouche, Michael Yin, Jing Ling, Thirupura S Shankar, Eugene Kwan, Luis Cedeno-Rosaria, Jesse N Velasco-Silva, Konstantinos Sideris, Hyoin Kwak, Yanni Hillas, Eleni Yannias, Eleni Maneta, Harini Srinivasan, Laisha Padilla, Georgiy Polishchuck, Sutip Navankasattusas, Anwar Tandar, Gregory S Ducker, Jared Rutter, TingTing Hong, Robin M Shaw, Charles Lui, Frederick G Welt, Stavros G Drakos
bioRxiv [Preprint]. 2025 Feb 15:2025.02.11.637726 PMCID: PMC11844558
Jesse N Velasco‐Silva, Joseph L Wilkerson, Daniela Ramos, Hayden K Low, Faith Bowman, Kimberley J Evason, Sihem Boudina, William L Holland, Gregory S Ducker
Physiol Rep. 2025 May 26;13(10):e70381 PMCID: PMC12106947
Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation
Jiemin Nah, Sreya Mahendran, Baptiste Kerouanton, Liang Cui, Daniella H Hock, Alfredo Cabrera-Orefice, Kyle Dunlap, David Robinson, Desmond W H Tung, Sze Huey Leong, Kiat-Yi Tan, Sonia P Chothani, Jingjing Sun, Agnieszka Dziegowska, Grazyna Leszczynska, Owen J L Rackham, Ilka Wittig, Peter Dedon, Gregory S Ducker, David A Stroud, Lena Ho
Mol Cell. 2025 Jul 17;85(14):2759-2775.e12 PMID: 40578345
Hyperlipidemia drives tumor growth in a mouse model of obesity-accelerated breast cancer growth
Renan FL Vieira, Sawyer R Sanchez, Menusha Arumugam, Peyton D Mower, Meghan C Curtin, Abigail E Jackson, Molly R Gallop, Jillian Wright, Alexis Bowles, Gregory S Ducker, Keren I Hilgendorf, Amandine Chaix
Cancer Metab. 2025 Aug 28;13:39 PMCID: PMC12395885
Leveraging genetic and phenotypic variation to discover metabolite-protein interactions
Gregory S Ducker, Jared Rutter
Cell Metab. 2025 Nov 4;37(11):2105-2106 PMID: 41192359
MicroRNA-21 promotes dysregulated lipid metabolism and hepatocellular carcinoma
Chad VanSant-Webb, Jessye C Castro, Audrey Y Su, Kiandra Hawkins, Aavrati Saxena, Jillian Wright, Richard Smith, Marco Fragoso-García, Yian Ann Chen, Carrie Barton, Chris Stubben, Ryan M O'Connell, Gregory S Ducker, Kimberley J Evason
Dis Model Mech. 2026 Mar 5;19(2):dmm052583 PMCID: PMC12994464
Ezra Johnson, Joseph R Visker, Ben J Brintz, Christos P Kyriakopoulos, James Jeong, Yuyu Zhang, Thirupura S Shankar, Yanni Hillas, Iosif Taleb, Rachit Badolia, Junedh M Amrute, Chris J Stubben, Luis Cedeno-Rosario, Ioannis Kyriakoulis, Konstantinos Sideris, Jing Ling, Rana Hamouche, Eleni Tseliou, Sutip Navankasattusas, Gregory S Ducker, Jared Rutter, William L Holland, Scott A Summers, TingTing Hong, Steven C Koenig, Thomas C Hanff, Kory J Lavine, Tom Greene, Stephen Bailey, Rami Alharethi, Craig H Selzman, Palak Shah, Hongchao Guo, Mark S Slaughter, Manreet K Kanwar, Stavros G Drakos
bioRxiv [Preprint]. 2026 Apr 22:2026.04.21.720029 PMCID: PMC13131776
Visker JR, Tseliou E, Kyriakopoulos CP, Hamouche R, Yin M, Ling J, Shankar TS, Kwan E, Cedeno-Rosaria L, Velasco-Silva JN, Sideris K, Kwak H, Hillas Y, Yannias E, Maneta E, Srinivasan H, Padilla L, Polishchuck G, Navankasattusas S, Tandar A, Ducker GS, Rutter J, Hong T, Shaw RM, Lui C, Welt FG, Drakos SG.
bioRxiv [Preprint]. 2025 Feb 15:2025.02.11.637726. PMID: 39990383
Lee HM, Muhammad N, Lieu EL, Cai F, Mu J, Ha YS, Cao G, Suchors C, Joves K, Chronis C, Li K, Ducker GS, Olszewski K, Cai L, Allison DB, Bachert SE, Ewing WR, Wong H, Seo H, Kim IY, Faubert B, Kim J, Kim J.
Nat Metab. 2024 Jul;6(7):1310-1328. doi: 10.1038/s42255-024-01066-z. Epub 2024 Jun 14.PMID: 38877143
SLC7A5 is required for cancer cell growth under arginine-limited conditions.
Dunlap KN, Bender A, Bowles A, Bott AJ, Tay J, Grossmann AH, Rutter J, Ducker GS.
Cell Rep. 2025 Jan 3;44(1):115130. Online ahead of print.
Enhancing mitochondrial pyruvate metabolism ameliorates ischemic reperfusion injury in the heart
Visker JR, Cluntun AA, Velasco-Silva JN, Eberhardt DR, Cedeño-Rosario L, Shankar TS, Hamouche R, Ling J, Kwak H, Hillas JY, Aist I, Tseliou E, Navankasattusas S, Chaudhuri D, Ducker GS, Drakos SG, Rutter J.
JCI Insight. 2024 Nov 8;9(21):e187849. PMID: 39513362
Acuña-Pilarte K, Reichert EC, Green YS, Halberg LM, Golkowski M, Maguire KM, Mimche PN, Kamdem SD, Hu PA, Wright J, Ducker GS, Voth WP, O'Connell RM, McFarland SA, Egal ESA, Chaix A, Summers SA, Reelitz JW, Maschek JA, Cox JE, Evason KJ, Koh MY.
Hepatology. 2024 Sep 10. Online ahead of print.PMID: 39255518
VanSant-Webb C, Low HK, Kuramoto J, Stanley CE, Qiang H, Su A, Ross AN1, Cooper CG, Cox JE, Summers SA, Evason JE, Ducker GS.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. Volume 1869, Issue 6, 2024
Glycine homeostasis requires reverse SHMT flux
McBride MJ, Hunter CJ, Zhang Z, TeSlaa T, Xu X, Ducker GS, Rabinowitz JD.
Cell Metab. 2024 Jan 2
Lathen D, Merrill C, Ducker GS, Rodan AR, Rothenfluh A.
bioRxiv. 2022 Nov 14
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG.
Cell Metab. 2021 Mar 2;33(3):629-648. PMID: 33333007
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
García-Cañaveras JC, Lancho O, Ducker GS, Ghergurovich JM, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz JD.
Leukemia. 2021 Feb;35(2):377-388. Epub 2020 May 7. PMID: 32382081
Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis
Panic V, Pearson S, Banks J, Tippetts TS, Velasco-Silva JN, Lee S, Simcox J, Geoghegan G, Bensard CL, van Ry T, Holland WL, Summers SA, Cox J, Ducker GS, Rutter J, Villanueva CJ.
Elife. 2020 Aug 14;9:e52558. PMID: 32795388
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier
Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J.
Cell Metab. 2020 Feb 4;31(2):284-300.e7. Epub 2019 Dec 5. PMID: 31813825
Rodan LH, Qi W, Ducker GS, Demirbas D, Laine R, Yang E, Walker MA, Eichler F, Rabinowitz JD, Anselm I, Berry GT.
Molecular genetics and metabolism. 2018; 125(1-2):118-126.
Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP.
PloS one. 2018; 13(5):e0193849.
Mitochondrial translation requires folate-dependent tRNA methylation
Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD.
Nature. 2018; 554(7690):128-132. NIHMSID: NIHMS928014
Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD.
PNAS. 2017; 114(43):11404-11409.
An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate.
Chen L, Ducker GS, Lu W, Teng X, Rabinowitz JD.
Analytical and bioanalytical chemistry. 2017; 409(25):5955-5964. NIHMSID: NIHMS899140
One-Carbon Metabolism in Health and Disease.
Ducker GS, Rabinowitz JD.
Cell metabolism. 2017; 25(1):27-42. NIHMSID: NIHMS852041
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.
Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD.
Cell metabolism. 2016; 23(6):1140-1153. NIHMSID: NIHMS782486
ZMP: a master regulator of one-carbon metabolism.
Ducker GS, Rabinowitz JD.
Molecular cell. 2015; 57(2):203-4. NIHMSID: NIHMS695075
Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.
Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS.
Oncogene. 2014; 33(12):1590-600. NIHMSID: NIHMS550085
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma.
Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ.
Journal of neurosurgery. 2014; 120(2):331-6. NIHMSID: NIHMS981321
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.
Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D.
PNAS. 2013; 110(29):11988-93.
Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer.
Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM.
Investigational new drugs. 2012; 30(6):2219-25.
The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.
Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM.
PNAS. 2011; 108(37):15201-6.
McCormick SR, McCormick MJ, Grutkoski PS, Ducker GS, Banerji N, Higgins RR, Mendiola JR, Reinartz JJ.
Archives of pathology & laboratory medicine. 2010; 134(8):1143-51.
Synthesis and evaluation of indazole based analog sensitive Akt inhibitors
Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM.
Molecular bioSystems. 2010; 6(8):1389-402. NIHMSID: HHMIMS227289
Compartmental flexibility in mammalian folate metabolism
Ducker GS, Chen L, Teng X, Rabinowitz JD.
American Association for Cancer Research National Meeting; 2015 April; Philadelphia, PA. c 00.