Publications

Phospholipid isotope tracing reveals β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma

VanSant-Webb C, Low HK, Kuramoto J, Stanley CE, Qiang H, Su A, Ross AN1, Cooper CG, Cox JE, Summers SA, Evason JE, Ducker GS.

BioRxiv. 2023 Oct 16

One-carbon Pathways and Methylation Potential in Glutamatergic Neurons Regulate Behavioral Alcohol Responses

Lathen D, Merrill C, Ducker GS, Rodan AR, Rothenfluh A.

BioRxiv. 2022 Nov 14

The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG.

Cell Metab. 2021 Mar 2;33(3):629-648. PMID: 33333007

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

García-Cañaveras JC, Lancho O, Ducker GS, Ghergurovich JM, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz JD.

Leukemia. 2021 Feb;35(2):377-388. Epub 2020 May 7. PMID: 32382081

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis.

Panic V, Pearson S, Banks J, Tippetts TS, Velasco-Silva JN, Lee S, Simcox J, Geoghegan G, Bensard CL, van Ry T, Holland WL, Summers SA, Cox J, Ducker GS, Rutter J, Villanueva CJ.

Elife. 2020 Aug 14;9:e52558. PMID: 32795388

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J.

Cell Metab. 2020 Feb 4;31(2):284-300.e7. Epub 2019 Dec 5. PMID: 31813825

5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination

Rodan LH, Qi W, Ducker GS, Demirbas D, Laine R, Yang E, Walker MA, Eichler F, Rabinowitz JD, Anselm I, Berry GT.
Molecular genetics and metabolism. 2018; 125(1-2):118-126.

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.

Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP.
PloS one. 2018; 13(5):e0193849.

Mitochondrial translation requires folate-dependent tRNA methylation.

Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD.
Nature. 2018; 554(7690):128-132. NIHMSID: NIHMS928014

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.

Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD.
Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(43):11404-11409.

An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate.

Chen L, Ducker GS, Lu W, Teng X, Rabinowitz JD.
Analytical and bioanalytical chemistry. 2017; 409(25):5955-5964. NIHMSID: NIHMS899140

One-Carbon Metabolism in Health and Disease.

Ducker GS, Rabinowitz JD.
Cell metabolism. 2017; 25(1):27-42. NIHMSID: NIHMS852041

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.

Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD.
Cell metabolism. 2016; 23(6):1140-1153. NIHMSID: NIHMS782486

ZMP: a master regulator of one-carbon metabolism.

Ducker GS, Rabinowitz JD.
Molecular cell. 2015; 57(2):203-4. NIHMSID: NIHMS695075

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.

Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS.
Oncogene. 2014; 33(12):1590-600. NIHMSID: NIHMS550085

Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma.

Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ.
Journal of neurosurgery. 2014; 120(2):331-6. NIHMSID: NIHMS981321

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.

Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D.
Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(29):11988-93.

Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer.

Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM.
Investigational new drugs. 2012; 30(6):2219-25. 

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM.
Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(37):15201-6.

FLT3 mutations at diagnosis and relapse in acute myeloid leukemia: cytogenetic and pathologic correlations, including cuplike blast morphology.

McCormick SR, McCormick MJ, Grutkoski PS, Ducker GS, Banerji N, Higgins RR, Mendiola JR, Reinartz JJ.
Archives of pathology & laboratory medicine. 2010; 134(8):1143-51.

Synthesis and evaluation of indazole based analog sensitive Akt inhibitors.

Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM.
Molecular bioSystems. 2010; 6(8):1389-402. NIHMSID: HHMIMS227289

Compartmental flexibility in mammalian folate metabolism
Ducker GS, Chen L, Teng X, Rabinowitz JD.
American Association for Cancer Research National Meeting; 2015 April; Philadelphia, PA. c 00.